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| Tools for DNA Diagnostics | As more and
more of the human genome is mapped out and its thousands of individual
genes sequenced under the auspices of the Human Genome Project (HGP),
the commercial potential of DNA diagnostic technologies increases.
In 1997, the DNA-based portion of the in-vitro diagnostics industry
is projected to account for roughly $500 million, up dramatically
from its $58 million portion of a $5 billion industry in 1992.
The Tools for DNA Diagnostics program, which is part of the Advanced Technology Program, aims to accelerate the HGP payoff by supporting development of low-cost DNA sequencing and recognition tools and techniques that would strengthen and help create commercial opportunities in diagnostic and therapeutic arenas. The new program will foster development of diagnostic methods, instrumentation, and data-handling protocols that will speed up DNA analyses and sequence interpretation by a factor of 10 or more at costs of about one-tenth or even one-hundredth of present costs, which are $100 or more per test.
Meeting these goals will require the synergy of engineers, physicists, chemists, mathematicians, computer scientists, instrument designers, molecular biologists, and physicians. Among their goals will be to develop easy-to-use methods and miniaturized tools that can rapidly analyze minute quantities of DNA from human patients as well as agricultural plants and livestock. In the longer term, improved abilities to sequence and analyze ever smaller DNA samples more quickly should increase activity and decrease costs in settings as disparate as healthcare, forensics, toxicology, environmental monitoring, and quality control in the food industry.
Return to Press Release - April 1994
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| Information Infrastructure for Healthcare | The
U.S. healthcare industry has a pivotal role in the economic health
of the country. Medical spending is expected to top $1 trillion
in 1994, and conservative estimates figure 20 percent of today's
healthcare costs are related to the processing of information. The
U.S. healthcare industry stands at a critical juncture. While facing
a significant increase in the number of customers who will need
to be served, the industry is being tasked with increasing the quality
of results, ensuring consistent quality between rural and urban
providers, being accountable for outcomes on both an individual
and national scale, and providing accurate measures of success--while
also lowering costs. Information technology forms an important part
of the solution.
Applying the National Information Infrastructure to healthcare is extraordinarily simple to understand--information technology can greatly enhance healthcare services and efficiency. Yet implementing such an infrastructure in the real-world healthcare environment is confounding at best. This program is designed to help bridge the gap between the dream and reality. In an area as complex as the nation's healthcare enterprise, diverse information systems must be integrated in a way that helps, not hinders, the work of individual healthcare providers. To be most effective, the infrastructure development for information systems must be driven by what the user needs, not by what technology is available. The Advanced Technology Program focused program will help lay the foundation for a healthcare information infrastructure by funding the development of underlying infrastructural technologies, tools to make the infrastructure efficient and user friendly, and healthcare-specific applications. With support from major industry efforts that have begun to address interoperability issues, ATP funding will help drive sorely needed advances in healthcare information systems.
Otherwise, the islands of automation that already exist in some medical facilities will grow in isolation rather than into a seamless, interconnected infrastructure. The enabling technologies and coordination resulting from ATP funding can serve as the catalyst for bringing the disparate healthcare sectors together, ultimately providing substantial cost savings to the economy, while also strengthening the U.S. healthcare industry and the people it serves.
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| Manufacturing Composite Structures | The
market potential for high-performance composites made of polymers
reinforced with high-strength glass or ceramic fibers reaches into
the tens of billions of dollars, according to those who would make
and use the materials in the automotive, civil infrastructure, and
offshore oil industries. Already for decades, these materials have
played key roles in enhancing the performance of military aircraft
and missiles. They also have had smaller niche roles in the civil
aerospace and sports equipment industries. But they have yet to
penetrate into large-scale commercial markets because they now are
too costly to manufacture and have been too unfamiliar to designers
and users.
The new Advanced Technology Program five-year focus in Manufacturing Composite Structures aims to provide the long-term industrial research support for the subsequent commercial development of affordable high-quality composites into large structures such as bridges, or manufactured products such as cars.
This program will support generic research toward cost-effective manufacturing technologies, integration of design and simulation methodologies, and the use of sensors for monitoring the composite's conditions during manufacturing and during its service lifetime. The program also will facilitate large-scale demonstrations that will build upon the technical results of the program and validate the cost competitiveness of the composites in commercial sectors including land-based transportation, civil infrastructure construction, and offshore oil drilling.
Return to Press Release - April 1994
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| Component-based Software | One
of the many paradoxes of the Information Age is that software --
the very essence of the automated systems that move and process
information, manage factories, maintain complex accounting and record-keeping
systems -- is produced by something much like 19th-century handcrafted
products. Shrink-wrapped commodity software for personal computers
accounts for about 15 percent of the market; the balance is made
up of large, custom systems for such things as financial services,
manufacturing, or chemical processing. These systems are custom-built
monoliths, produced one at a time at costs of up to tens of millions
of dollars. The failure rate for developing these systems -- projects
that are started but never become fully operational -- is reported
to be about 70 percent.
The Advanced Technology Program focused on Component-Based Software launches a five-year cooperative effort with U.S. software producers to change this. Drawing on research in automated software design and production, the program will seek to establish the technology foundation to enable fundamental changes in the software industry. In the long term, this program envisions that vendors would be able to develop and market small, broadly useful software components described by a formal specification that characterizes the logical and functional requirements and characteristics of each component. Buyers in turn would be able to use similar formal specifications to characterize desired applications, and automated systems would match components with applications, reconfiguring the components as necessary to mesh with the final system. Conceptually, this is like marketing a light bulb that is automatically configured at the point of use to fit in whatever socket is there, at whatever voltage is present. As a result, software producers would be able to shift their emphasis from the mechanics of the software-development process to the more important task of meeting application needs by using automated tools to assemble and integrate independently produced components bought from specialized software component vendors.
While the United States clearly dominates the world software market today, foreign competition is growing steadily, particularly in the custom-system market directly addressed by this program. Moreover, the combination of lower cost, higher dependability, the ability to commercially address custom markets, and increased industry capacity should lead to greatly expanded markets for U.S.-produced software both at home and abroad.
The immediate business goals of the ATP program in Component-Based Software include enabling markedly increased productivity in software development through improved quality and reliability, reduced development time, and systematic reuse of components; enabling increased productivity for the users of major software systems through increased quality and dependability of systems built on reusable components; and extending the potential markets for U.S. software producers. This should enable software producers to concentrate on areas of specialization, bringing dramatic improvements in the quality and dependability of software, and expanding markets both at home and abroad for U.S. software. The success of this program should have a major impact in making it easier to produce the highly complex, integrated systems envisioned for the National Information Infrastructure.
Return to Press Release - April 1994
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| ATP FOCUSED PROGRAM | |
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| Computer-Integrated Manufacturing for Electronics | Electronic
products--from silicon chips packed with millions of minuscule devices
to global satellite communications systems--are essential elements
of nearly every component of the commercial landscape. An expanding
international market that exceeds $700 billion attests to both their
indispensability and pervasiveness. The some 16,000 U.S. electronics
firms vying in this diverse, fiercely competitive global market
employ 1.7 million people, more workers than the next three largest
manufacturing industries combined.
Of the many determinants of competitiveness in electronics, speed and agility are especially critical. An unabating stream of innovations embedded in new product offerings is reducing the shelf life of products and favoring companies that are quick to identify market opportunities and first to develop and introduce new products. At the same time, the costs of state-of-the-art manufacturing capabilities are soaring A factory for making integrated circuits, for example, now requires a $1 billion investment.
The new Advanced Technology Program focused on Computer-Integrated Manufacturing (CIM) for Electronics aims to foster development and application of information technologies and systems-engineering techniques that will enable greater manufacturing flexibility, greater product variety, and speedier responses to market opportunities. The technical objective is to develop a flexible software-based framework for integrating manufacturing-production functions.
Today's proprietary software systems are costly and take a long time to develop and perfect. But their greatest deficiency may be the inflexibility they impose on manufacturing operations. Changes introduce the risk of upsetting processes, reducing output, raising production costs, and delaying responses to market shifts.
With interoperable CIM software for production applications, electronics firms could scale up and reconfigure their manufacturing operations. In much the same way that personal computer users can create their own tailor-made systems from standard components such as disk drives, monitors, or even music keyboards -- all made by different equipment makers -- companies will be able to assemble and revamp their manufacturing systems with modular hardware and software components.
A widely adopted framework for designing and implementing interoperable software applications enables efficient re-engineering of manufacturing operations, which can reduce factory start-up times by 30 percent and halve the time and cost now required to bring new electronics products to market. Even if only 10 percent of U.S. electronics firms adopted integrated CIM technologies, gains in sales revenues stemming from these manufacturing improvements could total over $200 billion after seven years. Just as critical, the framework would create a lucrative market for independent developers of software for integrated production applications, spurring the growth of a supplier industry now confined to only a few general applications.
Among manufacturers and their suppliers of CIM software and other supporting information technology products, there is no clear view on which integration approach will dominate. ATP funding will help industry to sharpen its focus and give it the momentum needed to overcome technical barriers and to progress efficiently toward full integration.
Return to Press Release - April 1994
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Date created: April
1994
Last updated:
April 12, 2005
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