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Mark Arnold
Department of Chemistry
Optical Science and Technology Center
University of Iowa

Education

    Indiana University Purdue University at Indianapolis;Chemistry
    University of Delaware;Analytical Chemistry

Professional Experience
    Professor of Chemistry, University of Iowa; 1994-Present
    Associate Professor of Chemistry, University of Iowa; 1988-1994
    Assistant Professor of Chemistry, University of Iowa; 1982-1988

Professional Recognition

    Faculty Scholar Award; University of Iowa; 1997-1999.

    Invited speaker at the first Gordon Research Conference on Chemical Sensors and Interfacial Design; 1996.

    Noninvasive in vivo sensing research featured in Chemical & Engineering News; March 18, 1996.

    Glutamate biosensor research featured in Chemical & Engineering News; Sep. 13, 1993.

    Noninvasive blood glucose sensing research featured in Science; Nov. 6, 1992.

    Faculty Developmental Assignment; University of Iowa; 1990.

    Invited speaker at the first Gordon Conference on Bioanalytical Sensors; 1988.

    Old Gold Summer Research Fellowship, University of Iowa; 1985.

    Old Gold Summer Research Fellowship, University of Iowa; 1984.

    Society of Analytical Chemists of Pittsburgh Starter Grant Program Award; 1983.

    Old Gold Summer Research Fellowship, University of Iowa; 1983.

    DuPont Chemistry Research Fellowship, University of Delaware; 1981.

Selected Patents (6 total)

Chaung, H; Arnold, MA; U.S. Patent Application: Optical sensor with radioluminescent light source; filed February 1996.

Small, GW; Arnold, MA; PCT Patent Application: Method and apparatus for non-invasive determination of physiological chemicals, particularly glucose; PCT/US95/01556; filed February 7, 1995; International Publication No. WO 95/22046.

Small, GW; Arnold, MA; U.S. Patent: Method and apparatus for non-invasive determination of physiological chemicals, particularly glucose; #5,459,317, October 17, 1995.

Selected Publications (108 total)

  1. Burmeister, JJ; Arnold, MA; Evaluation of measurement sites for noninvasive blood glucose sensing with near infrared transmission spectroscopy, Clinical Chemistry 1999, in press.
  2. Razek, TMA; Miller, MJ; Hassan, SSM; Arnold, MA; Optical sensor for sulfur dioxide based on fluorescence quenching, Talanta 1999, in press.
  3. Riley, MR; Arnold, MA; Murhammer, DW; Effect of sample complexity on quantification of analytes in aqueous samples by near infrared spectroscopy; (1999) submitted for publication.
  4. Hu, SB; Lillquist, A; Arnold, MA; Wiencek, JM; Partial-least squares analysis of lysozyme near-infrared spectra; Applied Biochemistry and Biotechnology 1999, in press.
  5. Chuang, H; Arnold, MA; Radioluminescent sources for optical chemical sensors; Proceedings of the 15th IUPAC International Conference on Chemical Education; Pure and Applied Chemistry, 1999, in press.
  6. Ding, Q; Small, GW; Arnold, MA; Evaluation of data pretreatment and model building methods for the determination of glucose from near-infrared single-beam spectra; Applied Spectroscopy 1999 53, 402-414.
  7. Ding, Q; Small, GW; Arnold MA; Evaluation of nonlinear model building strategies for the determination of glucose in biological matrices by near-infrared spectroscopy; Analytical Chimica Acta 1999 384, 333-343.
  8. Ding, Q; Small, GW; Arnold, MA; Genetic algorithm-based wavelength selection for the near infrared determination of glucose in biological matrices: Initialization strategies and effects of spectral resolution; Analytical Chemistry 1998 70, 4472-4479.
  9. Spear, SK; Martin, Rhiel, Murhammer, DW; Arnold, MA; Ammonia measurements in mammalian cell culture media with a diffuse reflectance based fiber-optic ammonia sensor; Applied Biochemistry and Biotechnology 1998 75, 175-186.
  10. Razek, TMA; Spear, S; Hassan, SSM; Arnold, MA; Selective measurement of chromium (VI) by fluorescence quenching of ruthenium; Talanta 1999 48, 269-275.
  11. Spear, SK; Patterson, SL; Arnold, MA; Flow through fiber optic ammonia sensor for analysis of hippocampus slice perfusates; Analytica Chimica Acta 1998 357, 79-84.
  12. Hazen, KH; Arnold, MA; Small, GW; Measurement of glucose in water with first overtone near infrared spectra; Applied Spectroscopy 1998 52, 1597-1605.
  13. Riley, MR; Arnold, MA; Murhammer, DW; Matrix-enhanced calibration procedure for multivariate calibration models with near-infrared spectra; Applied Spectroscopy 1998 52, 1339-1347.
  14. Hazen, KH; Arnold, MA; Small, GW; Measurement of glucose and other analytes in undiluted human serum with near infrared transmission spectroscopy; Analytica Chimica Acta 1998 371, 255-267.
  15. Riley, MR; Arnold, MA; Murhammer, DW; Adaptive calibration scheme for quantification of nutrients and byproducts in insect cell bioreactors by near infrared spectroscopy; Biotechnology Progress 1998 14, 527-533.
  16. Chuang, H; Arnold, MA; Linear calibration function for optical oxygen sensors based on quenching of ruthenium fluorescence; Analytica Chimica Acta 1998 368, 83-89.
  17. Burmeister, JJ; Arnold, MA; Small, GW; Spectroscopic considerations for noninvasive blood glucose measurements with near infrared spectroscopy; IEEE Lasers and Electro-Optics Society 1998 12, 6-9.
  18. Small, GW; Arnold, MA; Data handling issues for near-infrared glucose measurements; IEEE Lasers and Electro-Optics Society 1998 12, 16-17.
  19. Arnold, MA; Burmeister, JJ; Small, GW; Phantom glucose calibration models from simulated noninvasive human near infrared spectra; Analytical Chemistry 1998 70, 1773-1781.
  20. Burmeister, JJ; Chung, H; Arnold, MA; Phantoms for noninvasive blood glucose sensing with near-infrared transmission spectroscopy; Photochemistry and Photobiology (Symposium-in-print) 1998, 67, 50-55.
  21. Wang, P; Amarasinghe, S.; Leddy, J; Arnold, M.; Dordick, JS; Enzymatically prepared poly(hydroquinone) as a mediator for amperometric glucose sensors; Polymer 1997 39, 123-127.
  22. Mattu, MJ; Small, GW; Arnold, MA; Determination of glucose in a biological matrix by multivariate analysis of multiple bandpass-filtered Fourier transform near-infrared interferograms; Analytical Chemistry 1997 69, 4695-4702.
  23. Mattu, JM; Small, GW; Arnold, MA; Application of multivariate calibration techniques to quantitative analysis of bandpass filtered Fourier transform infrared interferogram data; Applied Spectroscopy 1997 51, 1369-1376.
  24. Lu, G; Zhou, X; Arnold, MA; Small, GW; Multivariate calibration models based on the direct analysis of near-infrared spectra; Applied Spectroscopy 1997 51, 1330-1339.
  25. Chuang, H; Arnold, MA; Radio-luminescent light source for optical oxygen sensors; Analytical Chemistry 1997 69, 1899-1903.
  26. Riley, MR; Rhiel, M; Zhou, X; Arnold, MA; Murhammer, DW; Simultaneous monitoring of glucose and glutamine in insect cell cultures by near infrared spectroscopy; Biotechnology and Bioengineering 1997 55, 11-15.
  27. Bangalore, AS; Shaffer, RE; Small, GW; Arnold, MA; Genetic algorithm based method for selecting wavelengths and model size for use with partial least-squares regression: application to near-infrared spectroscopy; Analytical Chemistry 1996 68, 4200-4212.
  28. Shaffer, RE; Small, GW; Arnold, MA; Genetic algorithm-based protocol for coupling digital filtering and partial least-squares regression: Application to the near-infrared analysis of glucose in biological matrices; Analytical Chemistry 1996 68, 2663-2675.
  29. Zhou, X; Arnold, MA; Response characteristics and mathematical model for a nitric oxide fiber-optic chemical sensor; Analytical Chemistry 1996 68, 1748-1754.
  30. Pan, S; Arnold, MA; Amperometric glutamate biosensor and the enhancement of selectivity with Nafion; Talanta 1996 43, 1157-1162.
  31. Pan, S; Chung, H; Arnold, MA; Small, GW; Near-infrared spectroscopic measurement of physiological glucose levels in variable matrices of protein and triglycerides; Analytical Chemistry 1996 68, 1124-1135.
  32. Arnold, MA; Noninvasive glucose monitoring; Current Opinion in Biotechnology 1996 7, 46-49.
  33. Chung, H; Arnold, MA; Rhiel, M; Murhammer, DW; Simultaneous measurements of glucose, glutamine, ammonia, lactate and glutamate in aqueous solutions by near-infrared spectroscopy; Applied Spectroscopy 1996 50, 270-276.
  34. Arnold, MA; New developments and clinical impact of noninvasive monitoring; in Handbook of Clinical Laboratory Automation, Robotics, and Optimization, (Kost, GJ, Ed); John Wiley & Sons; 1996, Chapter 26, pp. 631-647.

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